The 3Rs, or the replacement, reduction, and refinement of animal research, are widely accepted as the best approach to maximizing high-quality science while ensuring the highest standard of ethical consideration is applied in regulating the use of animals in scientific procedures. This contrasts with the muted scientific interest in the 3Rs when they were first proposed in The Principles of Humane Experimental Technique. Indeed, the relative success of the 3Rs has done little to encourage engagement with their original text, which (...) remains little read and out of print. By adopting a historical perspective, this article argues that one explanation for this disjunction may be found in another, more celebrated, event of 1959: C. P. Snow’s Rede lecture on The Two Cultures. The moral outlook of The Principles of Humane Experimental Technique derived from an earlier ethos wherein humanistic and scientific values occupied a shared culture. While the synthetic style of The Principles has hindered its readership, this article concludes that there is value to recovering the notion that the humanities and social sciences can contribute to the improvement of animal research. (shrink)

The scientific, personal, and social implications of this revolutionary work are staggering. MARGINS OF REALITY is nothing less than a fundamental reevaluation of how the world really works.

ABSTRACT:Neuroethics, the study of the cognitive and neural mechanisms underlying ethical decision-making, is a growing field of study. In this review, we identify and discuss four themes emerging from neuroethics research. First, ethical decision-making appears to be distinct from other types of decision-making processes. Second, ethical decision-making entails more than just conscious reasoning. Third, emotion plays a critical role in ethical decision-making, at least under certain circumstances. Lastly, normative approaches to morality have distinct, underlying neural mechanisms. On the basis of (...) these themes, we draw implications for research in business ethics and the practice of ethics training. (shrink)

In 1942 a coalition of twenty scientific societies formed the Conference on the Supply of Experimental Animals in an attempt to pressure the Medical Research Council to accept responsibility for the provision of standardised experimental animals in Britain. The practice of animal experimentation was subject to State regulation under the Cruelty to Animals Act of 1876, but no provision existed for the provision of animals for experimental use. Consequently, day-to-day laboratory work was reliant on a commercial small animal market which (...) had emerged to sustain the hobby of animal fancying. This paper explores how difficulties encountered in experimental practice within the laboratory led to the problematisation of biomedical science’s reliance upon a commercial market for animals during the inter-war period. This is shown to have produced a crisis within animal reliant experimental science in the early 1940s which enabled the left-wing Association of Scientific Workers to cast science’s reliance on a free market as economically inefficient and a threat to the reliability of British research. It is argued that the development of standard experimental animals in Britain was, therefore, embedded within the wider cultural, societal, political and economic national context of the time. (shrink)

This book demonstrates that the state-contingent approach provides the best way to think about all problems in the economics of uncertainty, including problems...

Natural selection is commonly interpreted as the fundamental mechanism of evolution. Questions about how selection theory can claim to be the all-sufficient explanation of evolution often go unanswered by today's neo-Darwinists, perhaps for fear that any criticism of the evolutionary paradigm will encourage creationists and proponents of intelligent design.In Biological Emergences, Robert Reid argues that natural selection is not the cause of evolution. He writes that the causes of variations, which he refers to as natural experiments, are independent of (...) natural selection; indeed, he suggests, natural selection may get in the way of evolution. Reid proposes an alternative theory to explain how emergent novelties are generated and under what conditions they can overcome the resistance of natural selection. He suggests that what causes innovative variation causes evolution, and that these phenomena are environmental as well as organismal.After an extended critique of selectionism, Reid constructs an emergence theory of evolution, first examining the evidence in three causal arenas of emergent evolution: symbiosis/association, evolutionary physiology/behavior, and developmental evolution. Based on this evidence of causation, he proposes some working hypotheses, examining mechanisms and processes common to all three arenas, and arrives at a theoretical framework that accounts for generative mechanisms and emergent qualities. Without selectionism, Reid argues, evolutionary innovation can more easily be integrated into a general thesis. Finally, Reid proposes a biological synthesis of rapid emergent evolutionary phases and the prolonged, dynamically stable, non-evolutionary phases imposed by natural selection. (shrink)

Frequent lateral genetic transfer undermines the existence of a unique “tree of life” that relates all organisms. Vertical inheritance is nonetheless of vital interest in the study of microbial evolution, and knowing the “tree of cells” can yield insights into ecological continuity, the rates of change of different cellular characters, and the evolutionary plasticity of genomes. Notwithstanding within-species recombination, the relationships most frequently recovered from genomic data at shallow to moderate taxonomic depths are likely to reflect cellular inheritance. At the (...) same time, it is clear that several types of ‘average signals’ from whole genomes can be highly misleading, and the existence of a central tendency must not be taken as prima facie evidence of vertical descent. Phylogenetic networks offer an attractive solution, since they can be formulated in ways that mitigate the misleading aspects of hybrid evolutionary signals in genomes. But the connections in a network typically show genetic relatedness without distinguishing between vertical and lateral inheritance of genetic material. The solution may lie in a compromise between strict tree-thinking and network paradigms: build a phylogenetic network, but identify the set of connections in the network that are potentially due to vertical descent. Even if a single tree cannot be unambiguously identified, choosing a subnetwork of putative vertical connections can still lead to drastic reductions in the set of candidate vertical hypotheses. (shrink)

The principles of the 3Rs—replacement, refinement, and reduction—strongly shape discussion of methods for performing more humane animal research and the regulation of this contested area of technoscience. This special issue looks back to the origins of the 3Rs principles through five papers that explore how it is enacted and challenged in practice and that develop critical considerations about its future. Three themes connect the papers in this special issue. These are the multiplicity of roles enacted by those who use and (...) care for animals in research, the distribution of “feelings that matter” across species and spaces of laboratory animal practice, and the growing importance of “cultures of care” in animal research. (shrink)

ABSTRACT In the context of the COVID-19 pandemic, leaders are facing an ethical dilemma and a tense tradeoff between employees’ health and economic performance. From the perspective of employees’ perceptions of the work situation, this study examines the way ethical leadership enhances employee creativity during the COVID-19 pandemic by using leader-member exchange and organizational ethical climate as mediators. The sample included 308 supervisor-employee pairs from 20 high-tech companies in eight provincial regions of China. Structural equation modeling was used to test (...) the proposed hypotheses. Results indicate that ethical leadership can significantly enhance employee creativity through the fully mediating roles of employees’ perceptions of leader-member exchange and organizational ethical climate. Moreover, leader-member exchange affects employee creativity directly as well as indirectly through the mediating role of organizational ethical climate. This study offers insights into the process linking ethical leadership to employee creativity and provides practical suggestions on ways of enhancing employee creativity in situations like the COVID-19 pandemic crisis. (shrink)

How do thought and language manage to be 'about' aspects of the world? J. Robert G. Williams investigates how representation arises out of a fundamentally non-representational world, showing the explanatory relations between the representational properties of language, of thought, and of perception and intention.

The six essays in this volume discuss philosophical thought on scientific theory including: a call for a realist, rather than instrumentalist interpretation of science; a critique of one of the core ideas of positivism concerning the relation between observational and theoretical languages; using aerodynamics to discuss the representational aspect of scientific theories and their isomorphic qualities; the relationship between the reliability of common sense and the authenticity of the world view of science; removing long-held ambiguities on the theory of inductive (...) logic; and the relationship between the actuality of conceptual revolutions in the history of science and traditional philosophical pictures of scientific theory-building. (shrink)

Ethics and Educational Research: An Introduction Robert G. Burgess Ethical questions are the subject of interdisciplinary discussions and debates. ...

The dominant model for interpreting brain imaging experiments assumes that the brain is organized to support mental processes that control behavior. However functional neuroimaging experiments, particularly of cognitive tasks, have not shown a high level of reproducibility and localization. This lack of clear functional segregation has been blamed on limitations in imaging technology and non linearity and regional overlap in how the brain implements these processes. However the validity of the underlying cognitive models used to describe the brain have rarely (...) been questioned or directly tested against imaging results. We propose an alternative model of brain function which correlates observed human behavior directly with measured brain activity without assumptions about intervening cognitive processes, that we term the Non-Cognitive Behavioral Model (NBM). Our model derives from Behavioral Psychology but is extended to include brain activations in addition to behavior as an observable. A further extension is the role of neuroplasticity as opposed to innate cognitive processes in the development of the brains support of cognitive behavior. Applications of NBM to neuroimaging studies are described and contrasted with the standard methodology which we refer to as the Standard Cognitive Model (SCM). In one application, the NBM correctly predicted the global, total energy consumption as the brain parameter that best correlates with a person being in the state of consciousness, a correlation missed by studies using the SCM due to its assumption that global activity does not support cognitive processes. Neuroplasticity is shown to provide a natural explanation of findings that object recognition activating the fusiform facial area comes from expertise through raining as opposed to the SCM explanation of an innate cognitive process specialized for face recognition. The conclusions are generalized to explain the poor reproducibility of cognitive processes reported in functional neuroimaging and to suggest how such studies can be used to better explain how the brain supports behavior. (shrink)

Shame and shame reactions are two of the most delicate and difficult issues of psychotherapy and are among the most likely to defy our usual dynamic, systemic, and behavioral theories. In this groundbreaking new collection, _The Voice of Shame_, thirteen distinguished authors show how use of the Gestalt model of self and relationship can clarify the dynamics of shame and lead us to fresh approaches and methods in this challenging terrain. This model shows how shame issues become pivotal in therapeutic (...) and other relationships and how healing shame is the key to transformational change. The contributors show how new perspectives on shame gained in no particular area transfer and generalize to other areas and settings. In so doing, they transform our fundamental understanding of psychotherapy itself. Grounded in the most recent research on the dynamics and experience of shame, this book is a practical guide for all psychotherapists, psychologists, clinicians, and others interested in self, psychotherapy, and relationship. This book contains powerful new insights for the therapist on a full-range of topics from intimacy in couples to fathering to politics to child development to gender issues to negative therapeutic reactions. Filled with anecdotes and case examples as well as practical strategies, _The Voice of Shame_ will transform your ideas about the role of shame in relationships - and about the potential of the Gestalt model to clarify and contextualize other approaches. (shrink)

In 1993, an astonishing discovery was made at a tomb in Guodian in Hubei province. Written on strips of bamboo that have miraculously survived intact since 300 B.C., the "Guodian Laozi," is by far the earliest version of the _Tao Te Ching_ ever unearthed. Students of ancient Chinese civilization proclaimed the text a decisive breakthrough in the understanding of this famous text: it provides the most conclusive evidence to date that the text was the work of multiple authors and editors (...) over hundreds of years, rather than the achievement of a single individual writing during the time of Confucius. Robert Henricks now presents the first English translation of the "bamboo slip Laozi." Differing substantially from other versions we have of the text, the Guodian Laozi provides us with clues on how and when the text came into being. As Henricks's translation shows, many chapters are missing in this form of the text, and some chapters remain incomplete. All of this seems to suggest that the _Tao Te Ching_ was not yet "complete" when these slips were copied. In his translation, Henricks focuses attention on lines in each of the chapters that vary from readings in other editions. In addition, he shows how the sequence of chapters in this form of the text is totally unrelated to the sequence readers commonly see in the "standard" form of the text, i.e., in other translations. Here are just a few of the noteworthy features of this new _Tao Te Ching:_ • A lucid introduction to the Guodian Laozi, offering background on the archaeological interpretation of the discovery • Line-by-line comparisons of the Guodian Laozi against the Mawangdui and Wang Bi editions • Extensive notes on each chapter describing the unique elements of the Guodian Laozi in comparison with other versions • Transcriptions for each chapter, noting both the ancient and modern form of the characters in the chapter • An appendix featuring the official biography of Laozi written by Sima Qian, the Grand Historian of China, as well as Henricks's commentary and notes on this biography This groundbreaking work will lead to a reassessment of the history and significance of this well-known and critical work as well as a reevaluation of the role it played in the development of Taoism in early China. (shrink)

Theoretical explication of a growing body of empirical data on consciousness-related anomalous phenomena is unlikely to be achieved in terms of known physical processes. Rather, it will first be necessary to formulate the basic role of consciousness in the definition of reality before such anomalous experience can adequately be represented. This paper takes the position that reality is constituted only in the interaction of consciousness with its environment, and therefore that any scheme of conceptual organization developed to represent that reality (...) must reflect the processes of consciousness as well as those of its environment. In this spirit, the concepts and formalisms of elementary quantum mechanics, as originally proposed to explain anomalous atomic-scale physical phenomena, are appropriated via metaphor to represent the general characteristics of consciousness interacting with any environment. More specifically, if consciousness is represented by a quantum mechanical wave function, and its environment by an appropriate potential profile, Schrödinger wave mechanics defines eigenfunctions and eigenvalues that can be associated with the cognitive and emotional experiences of that consciousness in that environment. To articulate this metaphor it is necessary to associate certain aspects of the formalism, such as the coordinate system, the quantum numbers, and even the metric itself, with various impressionistic descriptors of consciousness, such as its intensity, perspective, approach/avoidance attitude, balance between cognitive and emotional activity, and receptive/assertive disposition. With these established, a number of the generic features of quantum mechanics, such as the wave/particle duality, and the uncertainty, indistinguishability, and exclusion principles, display metaphoric relevance to familiar individual and collective experiences. Similarly, such traditional quantum theoretic exercises as the central force field and atomic structure, covalent molecular bonds, barrier penetration, and quantum statistical collective behavior become useful analogies for representation of a variety of consciousness experiences, both normal and anomalous, and for the design of experiments to study these systematically. (shrink)

Morrison offers an illuminating study of two linked traditions that have figured prominently in twentieth-century thought: Buddhism and the philosophy of Nietzsche. Nietzsche admired Buddhism, but saw it as a dangerously nihilistic religion; he forged his own affirmative philosophy in reaction against the nihilism that he feared would overwhelm Europe. Morrison shows that Nietzsche's influential view of Buddhism was mistaken, and that far from being nihilistic, it has notable and perhaps surprising affinities with Nietzsche's own project of the transvaluation of (...) all values. (shrink)

Identifying Consumption illustrates how an individual’s buying habits are shaped by the dynamics of the consumer marketplace—and thus how consumption and identity inform each other. Robert Dunn brings together the various theories of spending and develops a mode of analysis concentrating on the individual subjectivity of consumption. By doing so, he addresses how we spend and its relationship with status and lifestyle. Dunn provides a comprehensive guide to the study of modern consumer behavior before summarizing and critiquing the major (...) theories of consumption. At this juncture, he proposes a method of analysis that focuses on the significance of status and lifestyle in social relations that can help explain how the consumer marketplace is shaped. He concludes by raising issues about different ways of consuming and the relationship between consumption and identity. (shrink)

In this paper I examine the claim that mental causation — at least for cases involving the production of purposive behavior — is possible only if ‘mind/brain supervenience’ obtains, and suggest that in spite of all the bad press it has received in recent years, mind/brain supervenience is still the best way for a physicalist to solve the ‘exclusion problem’ that plagues many accounts of mental causation. In section 3, I introduce a form of mind/brain supervenience that depends crucially on (...) the idea that some brain state-types---namely, those involved in the production of purposive behavior---are nonlocally sensitive, where by ‘nonlocal sensitivity’ I mean cases where relevant causal histories and environmental circumstances effect a difference in some of an organism’s brain state-types intrinsic, causal properties. I will argue that such a mode of sensitivity of brain state-types offers the best way out of the exclusion problem for anyone convinced that mental state-types should be relationally individuated. (shrink)

Freud attributed uncovered incest, initially, to real abuse dissociated from self-consciousness, and later, to wishes repressed from consciousness. Dissociation is preferred on theoretical and empirical grounds. Whereas dissociation emerges from double-aspect materialism, repression implicates Cartesian dualism. Several studies suggest that abnormal individuals dissociate trauma from self-conscious source-monitoring, thereby convincing themselves that the trauma is imaginary rather than real, and re-experience the trauma as an unbidden image.

The general thrust of the dissertation may be captured by the following two claims: some mental properties play a causal role in the production of purposive behaviour; and both the intrinsic and extrinsic features of those properties may be causally efficacious in the production of such behaviour, is a claim in favour of mental causation; I take to be a claim in favour of what I refer to as an 'anti-individualistic' version of the doctrine. In the first two chapters, I (...) defend , whereas the third chapter supports claim . In the fourth chapter, I argue that the extrinsic, relational features of some mental properties have their own implementation mechanisms by which they control and structure behaviour. The last chapter, which is also the conclusion of the dissertation, is turned towards future research. It offers a general framework from which to investigate the role of semantic properties in the production of behaviour. The chapter also attempts to delineate the general features of an etiological approach to those properties. (shrink)

This volume centers on philosophical issues of the life sciences, particularly genetics and psychology, and the relevance of statistical data as the foundation for inductive reasoning in areas such as vaccination testing, population genetics, evolutionary theory, and natural selection. Also discussed is the role of psychology in defining thought processes, experiences, and behaviors and their subsequent relation to scientific discovery, and advancing knowledge of the human condition and human potential.

Significant to Dunn's critique of poststructuralist and postmodern theories is his application of George Herbert Mead as a means of theorizing identity and difference. The focus on postmodernity, rather than postmodernism grounds his analysis of identity and difference both materially and socially.

The revolution involving the foundations of the physical sciences heralded by relativity and quantum theories has been stimulating philosophers for many years. Both of these comprehensive sets of concepts have involved profound challenges to traditional theories of epistemology, ontology, and language. This volume gathers six experts in physics, logic and philosophy to discuss developments in space exploration and nuclear science and their impact on the philosophy of science.

Experimental data are often acclaimed on the grounds that they can be consistently generated. They are, it is said, reproducible. In this paper I describe how this feature of experimental-data (their pragmatic reliability) leads to their epistemic worth (their epistemic reliability). An important part of my description is the supposition that experimental procedures are to certain extent fixed and stable. Various illustrations from the actual practice of science are introduced, the most important coming at the end of the paper with (...) a discussion of Ray Davis' 1967 solar-neutrino detection experiment (as it is portrayed in Pinch, 1980). (shrink)